Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onset
Fergal M. Waldron, Tatiana Langerová, Aydan Rahmanova, Fiona L. Read, Holly Spence, Kristine Roberts, Angus D. Macleod, Samuel B. Pattle, Katie Hanna, Jenna M. Gregory
This study identifies pre-symptomatic TDP-43 pathology in skin and other peripheral organs up to 26.5 years before ALS diagnosis, suggesting skin as a potential biomarker for early detection.
bioRxiv · Apr 10, 2025 · PreprintNeuroscience