Holly Spence

This study uses machine learning to identify routine blood tests as predictive markers of pollution-related poor cognitive function in a cohort without neurological disease.

This study shows TDP-43 pathology occurs independently of stress granules in motor neurons, challenging existing models of TDP-43 pathogenesis.

This paper identifies distinct metabolic signatures in ALS subtypes defined by ferritin and TDP-43 pathology, supporting stratified therapeutic approaches.

The paper shows that amygdala TDP-43 pathology correlates with behavioural dysfunction and ferritin accumulation in sporadic ALS.

This study identifies brain region-specific TDP-43 pathology patterns in ageing, Alzheimer's disease, and amyotrophic lateral sclerosis, showing strong correlations with ferritin levels as a potential biomarker.

This study identifies pre-symptomatic TDP-43 pathology in skin and other peripheral organs up to 26.5 years before ALS diagnosis, suggesting skin as a potential biomarker for early detection.

This study examines sex differences in associations between systemic iron, inflammation markers, and subcortical brain iron levels in older adults.

This study uses an RNA aptamer to detect TDP-43 aggregation and shows that nuclear TDP-43 pathology and STMN-2 cryptic splicing occur before clinical symptoms in ALS.