NeurosciencebioRxivPreprint
Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onset
Fergal M. Waldron, Tatiana Langerová, Aydan Rahmanova…·Jenna M. Gregory
This study identifies pre-symptomatic TDP-43 pathology in skin and other peripheral organs up to 26.5 years before ALS diagnosis, suggesting skin as a potential biomarker for early detection.
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