Author

Samuel B. Pattle

NHS FifeORCID 0000-0003-0482-1909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Fergal M. WaldroniD· 2 shared Jenna M. GregoryiD· 2 shared Angus D. MacleodiD· 1 shared Aydan Rahmanova· 1 shared Fiona L. ReadiD· 1 shared Holly SpenceiD· 1 shared Judi O’ShaughnessyiD· 1 shared Judith A. Pate· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Fergal M. WaldronORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 10, 2025

Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onset

Fergal M. Waldron, Tatiana Langerová, Aydan Rahmanova…·Jenna M. Gregory

This study identifies pre-symptomatic TDP-43 pathology in skin and other peripheral organs up to 26.5 years before ALS diagnosis, suggesting skin as a potential biomarker for early detection.

10 citations

humanspatial transcriptomics

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NeurosciencebioRxivPreprintMar 17, 2022

pTDP-43 aggregates accumulate in the gut and other non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis

Samuel B. Pattle, Judi O’Shaughnessy, Olivia M. Rifai…·Jenna M. Gregory

The paper identifies pTDP-43 aggregates in non-CNS tissues of ALS patients prior to symptom onset, suggesting systemic pathology beyond the central nervous system.

1 citation

humanexperimental assay

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