Angus D. Macleod

Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onset

This study identifies pre-symptomatic TDP-43 pathology in skin and other peripheral organs up to 26.5 years before ALS diagnosis, suggesting skin as a potential biomarker for early detection.

Impaired value-based decision-making in Parkinson's Disease Apathy

This study investigates decision-making impairments in Parkinson's disease patients with apathy using reinforcement learning tasks and fMRI, finding reduced value-based choices and distinct neural activation patterns.