Author

Ayelet-Hashahar Orenbuch

Weizmann Institute of Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Saifeng ChengiD· 3 shared Yoav MayshariD· 3 shared Yonatan StelzeriD· 3 shared Amos TanayiD· 2 shared Netta Reines· 2 shared Tal Sokolov· 2 shared Akhiad Bercovich· 1 shared Aviezer LifshitziD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersGenomics

Saifeng ChengORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Vascular specification from diversified mesoderm culminates in endothelial convergence

Raz Ben Yair, Hernan Rubinstein, Yoav Mayshar, Tal Sokolov, Stephanie Gehrs, Liat Fellus‐Alyagor, Dana Hirsch, Netta Reines, Ayelet-Hashahar Orenbuch, Saifeng Cheng, Hellmut Augustin, Karina Yaniv, Amos Tanay, Yonatan Stelzer

This study reconstructs mouse vasculogenesis using single-cell and spatial analyses, revealing a transient vascular-primed state and the role of VEGF in endothelial specification.

bioRxiv · Oct 27, 2026 · PreprintDevelopmental Biology

A weak-interaction model defines the cell-autonomous function of DNA methylation in gastrulation

Saifeng Cheng, Roni Stok Ranen, Yoav Mayshar, Ofir Raz, Aviezer Lifshitz, Evgheni Casimov, Tal Sokolov, Akhiad Bercovich, Raz Ben-Yair, Oren Ben-Kiki, Netta Reines, Ayelet-Hashahar Orenbuch, Shuailin Du, Jinfang Wang, Zhu Y, , Amos Tanay

The paper introduces a weak-interaction model showing DNA methylation moderates, but does not block, trans-acting regulatory machineries during mouse gastrulation.

bioRxiv · May 14, 2026 · PreprintGenomics

Histone exchange sensors reveal variant specific dynamics in mouse embryonic stem cells

Marko Dunjić, Felix Jonas, Gilad Yaakov, Roye More, Yoav Mayshar, Yoach Rais, Ayelet-Hashahar Orenbuch, Saifeng Cheng, Naama Barkai, Yonatan Stelzer

The paper uses a histone exchange sensor to study variant-specific dynamics of histone incorporation and exchange in mouse embryonic stem cells, revealing variant-specific associations with transcription and Polycomb binding.

Nature Communications · Jun 26, 2023Peer-reviewedGenomics