Gilad Yaakov

Activator-binding domains are required but insufficient for Med15 recruitment to UAS, revealing a critical role for its disordered C-terminus in directing genome targeting

The paper shows that Med15's activator-binding domains are necessary but not sufficient for UAS recruitment, and its disordered C-terminus is critical for directing genome targeting.

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

Histone exchange sensors reveal variant specific dynamics in mouse embryonic stem cells

The paper uses a histone exchange sensor to study variant-specific dynamics of histone incorporation and exchange in mouse embryonic stem cells, revealing variant-specific associations with transcription and Polycomb binding.

Rtt109 promotes nucleosome replacement ahead of the replicating fork

The paper uses a histone exchange sensor to show Rtt109 promotes H3 replacement ahead of the replication fork in budding yeast, independent of H3K56 acetylation.

Gene transcription as a limiting factor in protein production and cell growth

The paper investigates how gene transcription limits protein production and cell growth by analyzing the effects of transcriptional feedback and its impact on cell size and division time.