Saturation mutagenesis map of generalist versus specialist adaptations of β-lactamase to novel antibiotics
Ilona Kamila Gaszek, Muhammed Sadik Yildiz, Levent Sari, Ayesha Ahmed, Erdal Toprak, Milo M. Lin
This study maps how β-lactamase mutations confer resistance to different antibiotics, identifying generalist and specialist mutations with distinct mechanisms and positions.
bioRxiv · Oct 14, 2025 · PreprintEvolutionary Biology