Sequestration of the phagocyte metabolite itaconate by P. aeruginosa RpoN promotes successful pulmonary infection
Ayesha Beg, Zihua Liu, Ying-Tsun Chen, Absar Talat, Griffin Gowdy, James Kyle Miller, Lindsey C. Florek, Lars E. P. Dietrich, Chu Wang, Ian A. Lewis, Tania Fok Lung Wong, Sebastián Riquelme-Barrios, Alice S. Prince
This study shows that P. aeruginosa sequesters itaconate by binding it to RpoN, enhancing its metabolic adaptation and promoting pulmonary infection.
bioRxiv · Aug 7, 2025 · PreprintMicrobiology