Ying-Tsun Chen

T6SS mutants exploit itaconate to support infection of phagocytes

This study shows that Pseudomonas aeruginosa mutants lacking the H3-T6SS exploit itaconate to persist in phagocytes, enhancing their ability to cause chronic lung infections.

Sequestration of the phagocyte metabolite itaconate by P. aeruginosa RpoN promotes successful pulmonary infection

This study shows that P. aeruginosa sequesters itaconate by binding it to RpoN, enhancing its metabolic adaptation and promoting pulmonary infection.

Regulation of airway fumarate by host and pathogen promotes S. aureus pneumonia

This study shows that fumarate, regulated by host and pathogen, limits S. aureus growth by blocking metabolic pathways, while FumC enables adaptation through fumarate degradation and utilization.