Author

Ruben Boon

Broad InstituteORCID 0000-0002-9355-674XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Catherine M. VerfaillieiD· 2 shared Leo A. van GrunsveniD· 2 shared Alessandra QualizzaiD· 1 shared Aneta MalesaiD· 1 shared Ayla Smout· 1 shared Bernard K. van der VeeriD· 1 shared Burak ToprakhisariD· 1 shared Elise Anne van OsiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersDevelopmental Biology

Catherine M. VerfaillieORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Osmolar modulation drives reversible cell cycle exit and human pluripotent cell differentiation via NF-κB and WNT signaling

Jonathan Sai‐Hong Chui, Teresa Izuel Idoype, Alessandra Qualizza, Rita Pires de Almeida, Lindsey Piessens, Bernard K. van der Veer, Gert Vanmarcke, Aneta Malesa, Paraskevi Athanasouli, Ruben Boon, Joris Vriens, Leo A. van Grunsven, Kian Peng Koh, Catherine M. Verfaillie, Frederic Lluı́s

This study shows that hyperosmolar conditions induce cell cycle exit and differentiation in pluripotent cells through NF-κB and WNT signaling pathways.

Advanced Science · Dec 1, 2023Peer-reviewedDevelopmental Biology

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

Jonathan De Smedt, Elise Anne van Os, Irene Talón, Sreya Ghosh, Burak Toprakhisar, Rodrigo Madeiro da Costa, Samantha Zaunz, Marta Aguirre Vázquez, Ruben Boon, Pieter Baatsen, Ayla Smout, Stefaan Verhulst, Leo A. van Grunsven, Catherine M. Verfaillie

The paper introduces a computational tool to identify key transcription factors in lineage specification and validates PU.1 as a master regulator for generating LSEC-like cells from pluripotent stem cells.

Cell Death and Disease · Jan 14, 2021Peer-reviewedDevelopmental Biology