NeurosciencebioRxivPreprint
CHD8 haploinsufficiency alters the developmental trajectories of human excitatory and inhibitory neurons linking autism phenotypes with transient cellular defects
Carlo Emanuele Villa, Cristina Cheroni, Alejandro Tobon…·Gaia Novarino
This study shows that CHD8 haploinsufficiency disrupts human cortical development by altering neuron generation timing, leading to macrocephaly-like organoid enlargement and cell-type specific molecular defects.