Cristina Cheroni

COG5-mediated Golgi organization coordinates neural progenitor fate during human brain development

This study shows that COG5 deficiency disrupts Golgi organization and affects neural progenitor fate during human brain development through altered trafficking and glycosylation.

High resolution multi-scale profiling of embryonic germ cell-like cells derivation reveals pluripotent state transitions in humans

This paper establishes a defined feeder-free system to convert human PGC-like cells to pluripotent stem cells, tracking transcriptional and epigenomic transitions using multi-omic analysis.

A molecular cell atlas of endocrine signalling in human neural organoids

This paper creates a molecular atlas of endocrine signaling in human neural organoids by perturbing seven hormonal pathways and analyzing their effects on neurodevelopment.

Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution

The paper longitudinally profiles cerebellar organoids, benchmarks them against fetal data, and models mutations linked to autism and human brain evolution.

A mixture of endocrine disrupting chemicals linked to lower birth weight induces adipogenesis and transcriptional changes related to birth weight alterations and diabetes

This study shows that an EDC mixture linked to lower birth weight increases adipogenesis and induces transcriptomic changes associated with birth weight and diabetes.

Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single cell resolution

The paper develops and validates multiplexing strategies for brain organoids combined with single cell RNA-seq to study neurodevelopmental trajectories across multiple genetic lines.

Curation of causal interactions mediated by genes associated to autism accelerates the understanding of gene-phenotype relationships underlying neurodevelopmental disorders

The paper curates causal gene-protein interactions linked to autism and develops tools to explore their functional relationships with phenotypes and pathways.

GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders

This study shows that GTF2I dosage affects neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders using patient-derived organoids and mouse models.

Benchmarking brain organoid recapitulation of fetal corticogenesis

This study benchmarks brain organoid gene co-expression patterns against fetal corticogenesis to assess their alignment with in vivo development.

Novel antiviral interferon sensitive genes unveiled by correlation-driven gene selection and integrated systems biology approaches.

The paper identifies novel antiviral interferon-sensitive genes using correlation-driven gene selection and systems biology approaches in HCV-permissive cells.

CHD8 haploinsufficiency alters the developmental trajectories of human excitatory and inhibitory neurons linking autism phenotypes with transient cellular defects

This study shows that CHD8 haploinsufficiency disrupts human cortical development by altering neuron generation timing, leading to macrocephaly-like organoid enlargement and cell-type specific molecular defects.

Human cortical organoids expose a differential function of GSK3 on direct and indirect neurogenesis

This study uses human cortical organoids to show that GSK3 inhibition affects progenitor proliferation and tissue architecture, with specific impacts on outer radial glia and astrogenic lineage.

The eukaryotic Initiation Factor 6 (eIF6) regulates ecdysone biosynthesis by modulating translation in Drosophila

This study shows that eIF6 upregulation in Drosophila enhances general translation and inhibits ecdysone biosynthesis, affecting development and metabolism.