Christoph Sommer

This paper develops LICONN, a light-microscopy based method for synapse-level connectomic reconstruction of brain tissue using hydrogel expansion and deep learning.

This study develops and applies expansion microscopy to Arabidopsis root tissues, achieving improved resolution and visualizing subcellular structures.

The paper shows that spinal neuron diversity increases exponentially during frog metamorphosis as motor behavior shifts from swimming to limb use, with molecular similarities to mammalian circuits.

This paper introduces a method for saturated reconstruction of living brain tissue using advanced imaging and deep learning to achieve high-resolution, volumetric analysis of neural structures over time.

The paper introduces CATS, a method to map brain tissue architecture across scales, demonstrating its application to hippocampal mossy fiber circuitry.

This study shows that tissue-wide genetic effects override cell-intrinsic gene function in cortical neuron migration using MADM and single-cell analysis.

This study shows that Cul3 mutations in mice cause ASD-like behaviors and neuronal migration defects during brain development, but not in adults.

This study shows that CHD8 haploinsufficiency disrupts human cortical development by altering neuron generation timing, leading to macrocephaly-like organoid enlargement and cell-type specific molecular defects.