Single-molecule multimodal timing of in vivo mRNA synthesis
A.J. Sethi, Marco Guarnacci, Muhammad Bilal, Karthik Subramanian Krishnan, Azusa Hayashi, Madhu Mathi Kanchi, Takayuki Nojima, Thomas Preiß, Eduardo Eyras, Rippei Hayashi
This study directly sequences pre-mRNA to resolve transcription and processing at single-molecule resolution, revealing delayed splicing and m6A methylation preceding splicing.
bioRxiv · Apr 27, 2025 · PreprintGenomics