Thomas Preiß

SWARM resolves nanopore signal interference between RNA modification types and reveals splicing-shaped pseudouridylation

SWARM improves detection of RNA modifications by reducing false positives and reveals new splicing-related pseudouridylation patterns.

Single-molecule multimodal timing of in vivo mRNA synthesis

This study directly sequences pre-mRNA to resolve transcription and processing at single-molecule resolution, revealing delayed splicing and m6A methylation preceding splicing.

Prediction of m6A and m5C at single-molecule resolution reveals a cooccurrence of RNA modifications across the transcriptome

CHEUI predicts m6A and m5C modifications at single-molecule resolution, revealing co-occurrence of these modifications in mRNAs across cell lines and tissues.

Diffusional variance-determined stochastic translation efficiency

The paper introduces a method to quantify protein synthesis rates by analyzing ribosome co-localization dynamics on mRNA.

Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes

The paper introduces Sel-TCP-seq to study initiation factor dynamics, revealing staged initiation and co-translational assembly of initiation complexes in yeast and human cells.

Multiple links between 5-methylcytosine content of mRNA and translation

The paper investigates the relationship between m5C modification in mRNA and translation by analyzing polysome profiles and validating m5C sites across different cell lines.

RNAModR: Functional analysis of mRNA modifications in R

RNAModR provides a framework for analyzing mRNA modifications, enabling statistical evaluation of their distribution and functional insights.