Author

Madhu Mathi Kanchi

Australian National University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:long-read sequencing· 3 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Eduardo EyrasiD· 3 shared A.J. SethiiD· 2 shared Agin RavindraniD· 2 shared Marco GuarnacciiD· 2 shared Nikolay E. ShirokikhiD· 2 shared Rippei HayashiiD· 2 shared Thomas PreißiD· 2 shared Akanksha SrivastavaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBioinformatics

Eduardo EyrasORCID

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3 papers

Recent·Most cited

SWARM resolves nanopore signal interference between RNA modification types and reveals splicing-shaped pseudouridylation

Stefan Prodic, Alice Cleynen, Shafi Mahmud, Akanksha Srivastava, Agin Ravindran, Madhu Mathi Kanchi, Arash Hajizadeh Dastjerdi, A.J. Sethi, Miona Ćorović, Ronit Jain, Marco Guarnacci, Gabriela Santos Rodriguez, Grazi Vieira, Thomas Preiß, Robert J. Weatheritt, , Eduardo Eyras

SWARM improves detection of RNA modifications by reducing false positives and reveals new splicing-related pseudouridylation patterns.

bioRxiv · Jun 4, 2026 · PreprintBioinformatics

Single-molecule multimodal timing of in vivo mRNA synthesis

A.J. Sethi, Marco Guarnacci, Muhammad Bilal, Karthik Subramanian Krishnan, Azusa Hayashi, Madhu Mathi Kanchi, Takayuki Nojima, Thomas Preiß, Eduardo Eyras, Rippei Hayashi

This study directly sequences pre-mRNA to resolve transcription and processing at single-molecule resolution, revealing delayed splicing and m6A methylation preceding splicing.

bioRxiv · Apr 27, 2025 · PreprintGenomics

Biochemical-free enrichment or depletion of RNA classes in real-time during direct RNA sequencing with RISER

Alexandra Sneddon, Agin Ravindran, Somasundhari Shanmuganandam, Madhu Mathi Kanchi, Nadine Hein, Simon Jiang, Nikolay E. Shirokikh, Eduardo Eyras

RISER enables real-time RNA class enrichment or depletion during direct RNA sequencing, improving detection of low-abundance RNAs by reducing dominant RNA reads.

Nature Communications · May 24, 2024Peer-reviewedBioinformatics