Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis
E. R. Haberman, G. Sarker, B. A. Arus, S. Yilmaz-Ozcan, N. Martinez-Sanchez, E. Freibergerova, I. Fernandez-Gonzalez, C. Zentai, C. J. O. O'Brien, D. E. Grainger, S. Chakarov, A. Raimondi, M. Iannacone, M. Lopez, F. Ginhoux, A. I. Domingos
This paper identifies leptin receptor-expressing sympathetic perineurial cells that produce IL33, which prevents BAT inflammation and obesity by supporting thermogenesis and immune regulation.
bioRxiv · May 9, 2023 · PreprintPhysiology