A. Raimondi

A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism

The paper shows that EGFR signaling via non-clathrin endocytosis requires a tripartite organelle platform linking Ca2+ oscillations to mitochondrial metabolism and ATP production for actin remodeling and collective motility.

Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters

The paper introduces PRINCESS, a novel biosensor that simultaneously detects membrane contact sites and measures associated Ca2+ dynamics using splitFAST technology.

Addressing heterogeneity in direct analysis of Extracellular Vesicles and analogues using Membrane-Sensing Peptides as Pan-Affinity Probes

This paper introduces Membrane-Sensing Peptides (MSP) as universal affinity ligands for analyzing Extracellular Vesicles and analogues, demonstrating their ability to detect EV-associated epitopes in clinical samples without prior isolation.

EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genes

This study identifies EZH2 as a dependency in NUT carcinoma, showing that combining EZH2 and BET inhibitors synergistically blocks tumor growth and prolongs survival.

Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis

This paper identifies leptin receptor-expressing sympathetic perineurial cells that produce IL33, which prevents BAT inflammation and obesity by supporting thermogenesis and immune regulation.

SEC62 and TMX4 control asymmetric autophagy of the nuclear envelope upon LINC complex disassembly

The paper identifies SEC62 and TMX4 as regulators of asymmetric autophagy of the nuclear envelope during LINC complex disassembly in response to ER homeostatic changes.

Salivary gland macrophages assist tissue-resident CD8+ T cell immune surveillance

The paper uses imaging to show salivary gland TRM use unique motility and tissue macrophages assist in their surveillance.

A major Role for Nrf2 transcription factors in cell transformation by KSHV encoded oncogenes.

This study identifies Nrf2 transcription factors as key mediators of KSHV oncogene-induced cell transformation through the vGPCR-Ga13-RhoA signaling pathway and Erk1/2 MAPK activation.