Inflammatory ER Stress Responses Dictate the Immunopathogenic Progression of Systemic Candidiasis
D. Awasthi, S. Chopra, B. A. Cho, A. Emmanuelli, T. A. Sandoval, S.-M. Hwang, C.-S. Chae, C. Salvagno, C. Tan, L. Vasquez-Urbina, J. J. Fernandez Rodriguez, S. F. Santagostino, T. R. Iwawaki, E. A. Romero-Sandoval, M. Sanchez Crespo, , J. R. Cubillos-Ruiz
This study shows that IRE1 hyperactivation in myeloid cells during Candida albicans infection drives renal immunopathology and mortality, and inhibiting IRE1 reduces inflammation and improves survival.
bioRxiv · Nov 17, 2022Immunology