J. R. Cubillos-Ruiz

This study shows that IRE1 hyperactivation in myeloid cells during Candida albicans infection drives renal immunopathology and mortality, and inhibiting IRE1 reduces inflammation and improves survival.

This study introduces GoT, a high-throughput method linking single-cell genotypes and transcriptomes, revealing that somatic mutations' transcriptional effects depend on cell identity.