Author

D. Awasthi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1

Frequent Co-Authors

T. Parish· 3 shared A. J. Manning· 2 shared S. Ahmed· 2 shared A. Butts· 1 shared A. Emmanuelli· 1 shared A. Shelke· 1 shared B. A. Cho· 1 shared B. A. Simmons· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersMicrobiology

T. Parish

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Simultaneous carbon catabolite repression governs sugar and aromatic co-utilization in Pseudomonas putida M2

S. Shrestha, D. Awasthi, Y. Chen, J. W. Gin, C. J. Petzold, P. D. Adams, B. A. Simmons, S. Singer

This study investigates carbon catabolite repression in Pseudomonas putida M2 during simultaneous sugar and aromatic co-utilization, revealing simultaneous repression by sugars and aromatics and the role of crc and small RNAs.

bioRxiv · May 23, 2023 · PreprintMicrobiology

Inflammatory ER Stress Responses Dictate the Immunopathogenic Progression of Systemic Candidiasis

D. Awasthi, S. Chopra, B. A. Cho, A. Emmanuelli, T. A. Sandoval, S.-M. Hwang, C.-S. Chae, C. Salvagno, C. Tan, L. Vasquez-Urbina, J. J. Fernandez Rodriguez, S. F. Santagostino, T. R. Iwawaki, E. A. Romero-Sandoval, M. Sanchez Crespo, , J. R. Cubillos-Ruiz

This study shows that IRE1 hyperactivation in myeloid cells during Candida albicans infection drives renal immunopathology and mortality, and inhibiting IRE1 reduces inflammation and improves survival.

bioRxiv · Nov 17, 2022Immunology

Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis

C. Levine, R. Jadhav, P. Yan, K. Tsotetsi, X. Wang, D. Awasthi, C. Grady, A. Shelke, S. S. Daher, T. Richmann, R. Shrestha, P. Sukheja, J. Patel, P. R. Barnett, R. J. Dikdan, , P. Kumar

This paper develops amidase-dependent pyrazinoic acid prodrugs that bypass PncA activation, showing efficacy against PZA-resistant Mtb.

bioRxiv · Jul 5, 2022 · PreprintMicrobiology

Chemical exploration of a highly selective scaffold with activity against intracellular Mycobacterium tuberculosis

S. Njikan, S. Ahmed, A. J. Manning, D. Awasthi, Y. Ovechkina, S. chowdhury, A. Butts, T. Parish

The paper identifies thiourea derivatives with high potency against intracellular Mycobacterium tuberculosis and good selectivity over eukaryotic cells.

bioRxiv · Feb 18, 2022 · PreprintMicrobiology

Identification of novel chemical scaffolds that inhibit the growth of Mycobacterium tuberculosis in macrophages

S. Ahmed, A. J. Manning, L. Flint, D. Awasthi, T. Parish

This study identifies five chemical classes that inhibit intracellular Mycobacterium tuberculosis growth in macrophages, with some also active against extracellular bacteria.

bioRxiv · Sep 28, 2021Microbiology

Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis

M. B. McNeil, S. Chettiar, D. Awasthi, T. Parish

The paper shows that cell wall inhibitors enhance rifampicin accumulation in Mycobacterium tuberculosis by increasing cellular permeability, suggesting potential for improved tuberculosis treatment combinations.

bioRxiv · Sep 23, 2018Microbiology