Author

B. A. Cole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1

Frequent Co-Authors

J. D. Lippiat· 2 shared N. Pilati· 2 shared S. P. Muench· 2 shared A. C. Kalli· 1 shared C. W. G. Fishwick· 1 shared H. Dejakaisaya· 1 shared R. M. Johnson· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

J. D. Lippiat

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2 papers

Recent·Most cited

A molecular switch in RCK2 triggers sodium-dependent activation of KNa1.1 (KCNT1) potassium channels.

B. A. Cole, A. C. Kalli, N. Pilati, S. P. Muench, J. D. Lippiat

This paper identifies a molecular switch in the RCK2 domain of KNa1.1 channels that mediates sodium-dependent activation through conformational changes involving specific amino acid residues.

bioRxiv · Sep 28, 2023Biophysics

Structure-based identification and characterisation of novel inhibitors of KNa1.1 potassium channels, a stratified target for KCNT1-related epilepsy.

B. A. Cole, R. M. Johnson, H. Dejakaisaya, N. Pilati, C. W. G. Fishwick, S. P. Muench, J. D. Lippiat

This study identifies novel inhibitors of KNa1.1 potassium channels using cryo-EM structures and computational methods, showing improved potency over quinidine for KCNT1-related epilepsy treatment.

bioRxiv · Sep 26, 2019Pharmacology & Toxicology