Author

S. P. Muench

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 5 Assay:cryo-EM· 5 Research Focus:protein folding & dynamics· 4 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. P. Klebl· 6 shared F. Sobott· 4 shared H. D. White· 3 shared B. A. Cole· 2 shared D. Kontziampasis· 2 shared J. D. Lippiat· 2 shared M. S. C. Gravett· 2 shared M. Trebbin· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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6 shared papersBiochemistry

D. P. Klebl

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM

D. P. Klebl, S. N. McMillan, C. Risi, E. Forgacs, B. Virok, J. Atherton, M. Stofella, D. Winkelmann, F. Sobott, V. Galkin, P. J. Knight, S. P. Muench, C. Scarff, H. D. White

This paper uses time-resolved cryoEM to directly observe the swinging lever mechanism of myosin-5, showing its structural changes during ATP hydrolysis and force generation.

bioRxiv · Jan 5, 2024 · PreprintBiochemistry

A molecular switch in RCK2 triggers sodium-dependent activation of KNa1.1 (KCNT1) potassium channels.

B. A. Cole, A. C. Kalli, N. Pilati, S. P. Muench, J. D. Lippiat

This paper identifies a molecular switch in the RCK2 domain of KNa1.1 channels that mediates sodium-dependent activation through conformational changes involving specific amino acid residues.

bioRxiv · Sep 28, 2023Biophysics

Exploiting the Affimer platform against influenza A virus

O. Debski-Antoniak, A. Flynn, D. P. Klebl, C. Tiede, I. A. Wilson, S. P. Muench, D. Tomlinson, J. Fontana

This paper isolates and characterizes Affimers, antibody-like proteins, that inhibit influenza A virus H3 subtype infection in vitro and block HA-receptor interactions.

bioRxiv · Aug 22, 2023Microbiology

Exploiting cryo-EM structures of actomyosin-5a to reveal the physical properties of its lever

M. S. C. Gravett, D. P. Klebl, O. G. Harlen, D. J. Read, S. A. Harris, S. P. Muench, M. Peckham

This study uses cryo-EM and molecular dynamics to determine the structure and physical properties of Myo5a's lever, revealing its working stroke and implications for its walking mechanism.

bioRxiv · Mar 19, 2023Biophysics

The bacterial magnesium transporter MgtA reveals highly selective interaction with specific cardiolipin species

J. Weikum, J. Vandyck, S. Subramani, D. P. Klebl, M. Storflor, s. P. muench, S. Abel, F. Sobott, J. P. Morth

This study shows that the bacterial magnesium transporter MgtA has functional specificity for cardiolipin species, with maximum activity achieved when combining cardiolipin 16:0 and 18:1.

bioRxiv · Sep 27, 2021Biochemistry

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

R. E. Gough, M. C. Jones, T. Zacharchenko, S. Le, M. Yu, G. Jacquemet, s. P. muench, J. Yan, J. D. Humphries, C. Jorgensen, M. Humphries, B. T. Goult

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

bioRxiv · Mar 19, 2021Cell Biology

Need for speed: Examining protein behaviour during cryoEM grid preparation at different timescales

D. P. Klebl, M. S. C. Gravett, D. Kontziampasis, D. J. Wright, R. S. Bon, D. Monteiro, M. Trebbin, F. Sobott, H. D. White, M. Darrow, R. F. Thompson, s. P. muench

This study examines how different macromolecular complexes behave during cryoEM grid preparation at various timescales using three vitrification devices.

bioRxiv · May 14, 2020Biochemistry

Structure-based identification and characterisation of novel inhibitors of KNa1.1 potassium channels, a stratified target for KCNT1-related epilepsy.

B. A. Cole, R. M. Johnson, H. Dejakaisaya, N. Pilati, C. W. G. Fishwick, S. P. Muench, J. D. Lippiat

This study identifies novel inhibitors of KNa1.1 potassium channels using cryo-EM structures and computational methods, showing improved potency over quinidine for KCNT1-related epilepsy treatment.

bioRxiv · Sep 26, 2019Pharmacology & Toxicology

A Cryo-EM Grid Preparation Device for Time-Resolved Structural Studies

D. Kontziampasis, D. P. Klebl, M. G. Iadanza, C. A. Scarff, F. Kopf, F. Sobott, D. C. F. Monteiro, M. Trebbin, S. P. Muench, H. D. White

This paper introduces a cryo-EM grid preparation device that enables rapid mixing and vitrification, achieving sub 4 Å reconstructions for time-resolved structural studies.

bioRxiv · Mar 4, 2019Biophysics