The Energetics and Ion Coupling of Cholesterol Transport Through Patched1
B. Ansell, R. A. Corey, L. V. Viti, M. Kinnebrew, R. Rohatgi, C. Siebold, M. Sansom
The paper uses molecular dynamics simulations and biochemical assays to study cholesterol transport through PTCH1, finding energetic barriers and ion-coupling mechanisms for cholesterol export.
bioRxiv · Feb 14, 2023Biophysics