Author

K. E. Swearingen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 6 Research Focus:cell type annotation· 5 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

R. L. Moritz· 8 shared S. H. I. Kappe· 3 shared S. Kumar· 3 shared A. M. Vaughan· 2 shared M. J. Shears· 2 shared P. Sinnis· 2 shared S. E. Lindner· 2 shared A. E. Barry· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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8 shared papersMicrobiology

R. L. Moritz

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Global Release of Translational Repression Across Plasmodiums Host-to-Vector Transmission Event

K. T. Rios, J. P. McGee, A. Sebastian, R. L. Moritz, M. Feric, S. Absalon, K. E. Swearingen, S. E. Lindner

This study identifies the global release of translational repression in Plasmodium parasites during host-to-vector transmission using transcriptomics and proteomics.

bioRxiv · Feb 1, 2024 · PreprintMicrobiology

Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research

P. J. Reddy, Z. Sun, H. H. Wippel, D. H. Baxter, K. E. Swearingen, D. D. Shteynberg, M. K. Midha, M. J. Caimano, K. Strle, Y. Choi, A. P. Chan, N. J. Schork, R. L. Moritz

The paper constructs a proteome resource, Borrelia PeptideAtlas, by integrating transcriptomic and proteomic data from multiple B. burgdorferi isolates to identify common proteins across infective strains.

bioRxiv · Jun 16, 2023 · PreprintBiochemistry

Plasmodium GPI-Anchored Micronemal Antigen is essential for parasite transmission through the mosquito host

C. Jennison, J. M. Gibson, N. Hertoghs, D. A. Dankwa, S. Kumar, B. A. Abatiyow, M. Naung, N. K. Minkah, K. E. Swearingen, R. L. Moritz, A. E. Barry, S. H. I. Kappe, A. M. Vaughan

This study shows that GAMA is essential for Plasmodium sporozoite motility, egress from oocysts, and invasion of the vertebrate host, with distinct roles in each process.

bioRxiv · Feb 24, 2022 · PreprintMicrobiology

Plasmodium falciparum Calcium Dependent Protein Kinase 4 is critical for male gametogenesis and transmission to the mosquito vector

S. KUMAR, M. T. Haile, M. R. Hoopmann, L. T. Tran, S. A. Michaels, S. R. Morrone, K. K. Ojo, L. M. Reynolds, U. Kusebauch, A. M. Vaughan, R. L. Moritz, S. H. I. Kappe, K. E. Swearingen

This study shows that PfCDPK4 is essential for male gametogenesis in Plasmodium falciparum, affecting exflagellation and parasite transmission to mosquitoes.

bioRxiv · Jun 6, 2021Microbiology

Platelet Derived Growth Factor Receptor β (PDGFRβ) is a Host Receptor for the human malaria parasite adhesin TRAP

R. W. J. Steel, V. Vigdorovich, N. Dambrauskas, B. K. Wilder, S. A. Arredondo, D. Goswami, S. Kumar, S. Carbonetti, K. E. Swearingen, T. Nguyen, W. Betz, N. Camargo, B. S. Fisher, J. Soden, H. Thomas, , S. H. I. Kappe

The paper identifies hPDGFRβ as a host receptor for the malaria parasite TRAP, showing its role in sporozoite motility and infection.

bioRxiv · May 12, 2020Microbiology

Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites

S. E. Lindner, K. E. Swearingen, M. J. Shears, M. P. Walker, E. N. Vrana, K. J. Hart, A. M. Minns, P. Sinnis, R. L. Moritz, S. H. Kappe

This study identifies two waves of translational repression in malaria sporozoite maturation using transcriptomic and proteomic data from Plasmodium species.

bioRxiv · May 20, 2019 · PreprintMicrobiology

Proteomic Analysis of Plasmodium Merosomes: The Link Between Liver and Blood Stages in Malaria

M. J. Shears, R. Sekhar Nirujogi, K. E. Swearingen, S. Renuse, S. Mishra, P. Jaipal Reddy, R. L. Moritz, A. Pandey, P. Sinnis

This paper presents the first proteomic analysis of merosomes in Plasmodium berghei, identifying 1879 proteins and highlighting shared and unique features with blood stage proteomes.

bioRxiv · Mar 16, 2019Microbiology

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiation.

A. Jex, I. Mueller, S. Kappe, S. Mikolajcjak, J. Sattabongkot, R. Patrapuvich, S. Lindner, E. Flannery, C. Koepfli, B. Ansell, A. Lerch, K. E. Swearingen, S. J. Emery-Corbin, S. Charnaud, J. Smith, , V. Chuenchob

This study characterizes the transcriptome and histone epigenome of Plasmodium vivax sporozoites, revealing transcriptional and post-transcriptional control mechanisms and potential pathways for hypnozoite formation.

bioRxiv · Dec 3, 2018 · PreprintMicrobiology