Author

B. Chevalier

Primary ORCID profile (0000-0003-0863-6022 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

B. ChevalieriD1 paper · Hôpital Necker-Enfants Malades

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Delaunay-Moisan· 1 shared A. Edelman· 1 shared A. Golec· 1 shared A. Hatton· 1 shared A. Hinzpeter· 1 shared A. Premchandar· 1 shared A. Tatopoulos· 1 shared B. Douvry· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

A. Delaunay-Moisan

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2 papers

Recent·Most cited

Beyond Kaftrio: mechanistic insights to maximize N1303K-CFTR rescue

I. Pranke, V. Capurro, B. Chevalier, E. Pesce, V. Tomati, C. Pastorino, A. Hatton, S. Urien, M. Lena, E. Dreano, R. Bocciardi, F. Zara, S. Pantano, V. Terlizzi, C. Lucanto, , S. Bui

This study investigates the mechanism of N1303K-CFTR rescue by ELX/TEZ and ETI combotherapy, showing increased protein amounts and activity with potential clinical benefits.

bioRxiv · Feb 29, 2024 · PreprintPhysiology

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes

I. M. Pranke, B. Chevalier, A. Premchandar, N. Baatallah, K. F. Tomaszewski, S. Bitam, D. Tondelier, A. Golec, J. Stolk, G. L. Lukacs, P. S. Hiemstra, M. Dadlez, D. A. Lomas, J. A. Irving, A. Delaunay-Moisan, , A. Edelman

This study shows that Keratin 8 modulates ERAD complexes, enhancing degradation of misfolded proteins like Z-A1AT and F508del-CFTR, and suggests targeting K8 for therapeutic intervention in A1ATD.

bioRxiv · Feb 1, 2022Cell Biology