Author

P. S. Hiemstra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. C. M. Kroes· 1 shared A. Delaunay-Moisan· 1 shared A. Edelman· 1 shared A. Golec· 1 shared A. Hinzpeter· 1 shared A. K. Wouters· 1 shared A. L. Ryan· 1 shared A. L. van Rijn· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMicrobiology

A. C. M. Kroes

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells

C. R. Pothast, R. C. Dijkland, M. Thaler, R. S. Hagedoorn, M. G. Kester, A. K. Wouters, P. S. Hiemstra, M. J. van Hemert, S. Gras, J. F. Falkenburg, M. H. Heemskerk

The paper shows that CMV-specific T cells can cross-react with SARS-CoV-2, contributing to pre-existing immunity despite low sequence homology.

bioRxiv · Jul 31, 2022Immunology

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes

I. M. Pranke, B. Chevalier, A. Premchandar, N. Baatallah, K. F. Tomaszewski, S. Bitam, D. Tondelier, A. Golec, J. Stolk, G. L. Lukacs, P. S. Hiemstra, M. Dadlez, D. A. Lomas, J. A. Irving, A. Delaunay-Moisan, , A. Edelman

This study shows that Keratin 8 modulates ERAD complexes, enhancing degradation of misfolded proteins like Z-A1AT and F508del-CFTR, and suggests targeting K8 for therapeutic intervention in A1ATD.

bioRxiv · Feb 1, 2022Cell Biology

Breathing on Chip: Dynamic flow and stretch tune cellular composition and accelerate mucociliary maturation of airway epithelium in vitro

J. C. Nawroth, D. Roth, A. van Schadewijk, A. Ravi, T. I. Maulana, C. N. Senger, S. van Riet, D. K. Ninaber, D. Kraft, P. S. Hiemstra, A. L. Ryan, A. M. van der Does

This study shows that applying airflow and stretch to airway epithelial cultures on a chip accelerates mucociliary maturation and alters cellular composition to better mimic airway biology.

bioRxiv · May 7, 2021 · PreprintCell Biology

The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease

A. L. van Rijn, S. van Boheemen, E. C. Carbo, N. Pappas, I. Sidorov, H. Mei, M. Aanerud, P. Bakke, E. C. J. Claas, T. M. Eagan, P. S. Hiemstra, A. C. M. Kroes, J. J. C. de Vries

This study uses metagenomic next-generation sequencing to analyze the respiratory virome in COPD exacerbations, finding high sensitivity and specificity for viral detection and a correlation between viral presence and reduced bacteriophage abundance.

bioRxiv · Jan 2, 2019Microbiology