Author

J. A. Irving

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. A. Lomas· 2 shared A. Brewster· 1 shared A. C. Pearce· 1 shared A. Delaunay-Moisan· 1 shared A. Denis· 1 shared A. Dossang· 1 shared A. Edelman· 1 shared A. Fra· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

D. A. Lomas

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes

I. M. Pranke, B. Chevalier, A. Premchandar, N. Baatallah, K. F. Tomaszewski, S. Bitam, D. Tondelier, A. Golec, J. Stolk, G. L. Lukacs, P. S. Hiemstra, M. Dadlez, D. A. Lomas, J. A. Irving, A. Delaunay-Moisan, , A. Edelman

This study shows that Keratin 8 modulates ERAD complexes, enhancing degradation of misfolded proteins like Z-A1AT and F508del-CFTR, and suggests targeting K8 for therapeutic intervention in A1ATD.

bioRxiv · Feb 1, 2022Cell Biology

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

D. Lomas, J. A. Irving, C. Arico-Muendel, S. Belyanskaya, A. Brewster, M. J. B. Brown, C.-w. Chung, H. Dave, A. Denis, N. Dodic, A. Dossang, P. Eddershaw, D. Klimaszewska, I. Haq, D. Holmes, , A. C. Pearce

This study identifies a small molecule that stabilizes Z α1-antitrypsin, reduces polymerization, and increases its secretion in cells and mice.

bioRxiv · Jul 26, 2020Pharmacology & Toxicology

Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population

M. Laffranchi, E. L. K. Elliston, F. Gangemi, R. Berardelli, D. A. Lomas, J. A. Irving, A. Fra

The paper identifies and characterizes a novel alpha-1-antitrypsin variant, Gly349Arg, which is functionally deficient but not secretory impaired, highlighting the need for accurate genotyping in AATD patients.

bioRxiv · Oct 24, 2018Biochemistry