Author

M. L. Donnelly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Shen· 3 shared A. E. Rohlfing· 2 shared E. R. Forster· 2 shared B. E. Eckenroth· 1 shared C. Feliciano· 1 shared H. Benito de la Puebla· 1 shared J. W. Ribis· 1 shared M. Krasilnikov· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

A. Shen

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Author profile →

3 papers

Recent·Most cited

Development of a dual fluorescent reporter system in Clostridioides difficile reveals a division of labor between virulence and transmission gene expression

M. L. Donnelly, S. D. Shrestha, J. W. Ribis, P. Kuhn, C. Feliciano, A. Shen, M. Krasilnikov

This study develops a dual fluorescent reporter system to analyze toxin and sporulation gene expression in C. difficile, revealing a division of labor between virulence and transmission gene expression under specific growth conditions.

bioRxiv · Mar 3, 2022Microbiology

Differential Effects of 'Resurrecting' Cap Pseudoproteases during Clostridioides difficile Spore Germination

M. L. Donnelly, E. R. Forster, A. E. Rohlfing, A. Shen

This study investigates whether restoring the catalytic triad in C. difficile pseudoproteases CspC and CspA can revive their protease activity during spore germination, finding that catalytic triad presence does not guarantee protease function.

bioRxiv · Nov 26, 2019Biochemistry

The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals

A. E. Rohlfing, B. E. Eckenroth, E. R. Forster, Y. Kevorkian, M. L. Donnelly, H. Benito de la Puebla, S. Doublie, A. Shen

This study identifies CspC as a bile salt sensor for C. difficile spore germination and shows it also responds to amino acid and calcium co-germinants through specific residues.

bioRxiv · Nov 5, 2018Microbiology