Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy
B. Etemad, A. Vertesy, T. E. F. Kuijt, C. Sacristan, A. v. Oudenaarden, G. J. P. L. Kops
The paper shows that the SAC responds to intermediate microtubule occupancy by shedding the RZZS-MAD1/2 module but retaining the BUB1/R1 module, allowing SAC silencing at submaximal occupancy while maintaining reactivation potential.
bioRxiv · Nov 16, 2018Cell Biology