Cell BiologybioRxiv
Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy
B. Etemad, A. Vertesy, T. E. F. Kuijt…·G. J. P. L. Kops
The paper shows that the SAC responds to intermediate microtubule occupancy by shedding the RZZS-MAD1/2 module but retaining the BUB1/R1 module, allowing SAC silencing at submaximal occupancy while maintaining reactivation potential.
DOI 10.1242/jcs.231589