Author

C. Sacristan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:chicken / avian· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

G. J. P. L. Kops· 2 shared A. Buckle· 1 shared A. Fish· 1 shared A. Musacchio· 1 shared A. Perrakis· 1 shared A. v. Oudenaarden· 1 shared A. Vertesy· 1 shared B. Etemad· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

G. J. P. L. Kops

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3 papers

Recent·Most cited

Condensin reorganizes centromeric chromatin during mitotic entry into a bipartite structure stabilized by cohesin

C. Sacristan, K. Samejima, L. Andrade Ruiz, M. L. A. Lambers, A. Buckle, C. A. Brackley, D. Robertson, T. Hori, S. Webb, T. Fukagawa, N. Gilbert, D. Marenduzzo, W. C. Earnshaw, G. J. P. L. Kops

This study shows vertebrate centromeres form a bipartite structure during mitosis, stabilized by condensin and linked by cohesin, which prevents merotelic attachments and chromosomal instability.

bioRxiv · Aug 1, 2022 · PreprintCell Biology

Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy

B. Etemad, A. Vertesy, T. E. F. Kuijt, C. Sacristan, A. v. Oudenaarden, G. J. P. L. Kops

The paper shows that the SAC responds to intermediate microtubule occupancy by shedding the RZZS-MAD1/2 module but retaining the BUB1/R1 module, allowing SAC silencing at submaximal occupancy while maintaining reactivation potential.

bioRxiv · Nov 16, 2018Cell Biology

Dynamic Kinetochore Size Regulation Promotes Microtubule Capture And Chromosome Biorientation In Mitosis

C. Sacristan, M. Ahmad, J. Keller, J. Fermie, V. Groenewold, E. Tromer, A. Fish, R. Melero, J. M. Carazo, J. Klumperman, A. Musacchio, A. Perrakis, G. J. Kops

The paper shows that Spindly-based dynamic regulation of kinetochore size ensures proper microtubule capture and chromosome segregation by controlling corona expansion and shedding.

bioRxiv · Mar 12, 2018Cell Biology