Metabolic heritage mapping: heterogenous pools of cytoplasmic nucleotide sugars are selectively utilized by various glycosyltransferases
P. Sosicka, B. G. Ng, L. E. Pepi, A. Shajahan, M. Wong, D. A. Scott, K. Matsumoto, Z.-J. Xia, C. B. Lebrilla, R. S. Haltiwanger, P. Azadi, H. H. Freeze
The paper shows that cells use different pools of GDP-fucose for glycosylation, depending on the origin of the monosaccharide, and that this selection is tightly regulated.
bioRxiv · Nov 3, 2021Biochemistry