K. Matsumoto

Fetal Kidney Transplantation for In Utero Fetuses

This paper describes a novel fetal therapy approach using transplanted fetal kidneys from different species to provide a bridge to dialysis in affected fetuses, demonstrating successful urine production and long-term function without immunosuppressants.

Analysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O-fucose modification on EGF12 in human development

The paper analyzes O-fucose modification on NOTCH1 in POFUT1 S162L patient fibroblasts and finds reduced ligand binding and absence of O-fucose at EGF12.

Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity

This study investigates the effects of eIF5A hypusination inhibition on mitochondrial function and identifies MPV17L2 as a key regulator involved in mitochondrial integrity.

Deep learning for histopathological subtyping and grading of lung adenocarcinoma

This study develops CNNs to subtype and grade lung adenocarcinoma, achieving high accuracy and outperforming most pathologists in grading prediction.

Metabolic heritage mapping: heterogenous pools of cytoplasmic nucleotide sugars are selectively utilized by various glycosyltransferases

The paper shows that cells use different pools of GDP-fucose for glycosylation, depending on the origin of the monosaccharide, and that this selection is tightly regulated.

Emerging single cell endothelial heterogeneity supports sprouting tumour angiogenesis and growth

The paper identifies a novel endothelial cell population in tumors that contributes to vascularization and growth.

Simple amplicon sequencing library preparation for plant root microbial community profiling

The paper develops a simplified high-throughput method for 16S rRNA gene amplicon sequencing of plant root microbiota, showing improved microbial diversity capture compared to standard methods.

Red-beet betalain pigment inhibits amyloid-β aggregation and toxicity in amyloid-β expressing Caenorhabditis elegans model

This study shows red-beet betalain pigments inhibit amyloid-β aggregation and toxicity in a C. elegans model of Alzheimer's disease.

Lab-on-a-graphene-FET detection of key molecular events underpinning influenza virus infection and effect of antiviral drugs

This study uses graphene-FETs to detect molecular events during influenza infection and monitor antiviral drug effects in real-time.

Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn's disease-like murine ileitis via inhibition of inflammatory cytokine expression

This study shows that CN210, a quinazoline-based BET inhibitor, reduces inflammation in a murine model of Crohn's disease by inhibiting inflammatory cytokine expression and NF-κB/MAP kinase pathways.

CUB domain-containing protein 1 controls HGF responses by integrating Src and Met-STAT3 signaling

This study identifies CDCP1 as a key regulator of HGF signaling by integrating Src and Met-STAT3 pathways, showing its role in cell invasion and renal growth.

The effect of sword bean extract on the relationship between rheumatoid arthritis and periodontitis in mice

This study investigates how sword bean extract affects the interaction between rheumatoid arthritis and periodontitis in mice, finding that it reduces inflammation and bone resorption in both conditions.

Characterization of the gastric motility response to human motilin and erythromycin in human motilin receptor-expressing transgenic mice

This study shows that human motilin and erythromycin stimulate gastric motility in human motilin receptor-expressing transgenic mice through Ca2+ influx, suggesting these mice are useful for testing MTLR agonists.