Author

H. H. Freeze

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Shajahan· 1 shared A. Ueda· 1 shared B. G. Ng· 1 shared C. B. Lebrilla· 1 shared D. A. Scott· 1 shared E. Miyoshi· 1 shared H. Tahara· 1 shared H. Udono· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Shajahan

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Author profile →

2 papers

Recent·Most cited

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

Y. Harada, Y. Mizote, T. Suzuki, M. Nishida, T. Hiratsuka, A. Ueda, Y. Imagawa, K. Maeda, Y. Ohkawa, J. Murai, H. H. Freeze, E. Miyoshi, S. Higashiyama, H. Udono, N. Dohmae, , N. Taniguchi

This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.

bioRxiv · Oct 17, 2022Cancer Biology

Metabolic heritage mapping: heterogenous pools of cytoplasmic nucleotide sugars are selectively utilized by various glycosyltransferases

P. Sosicka, B. G. Ng, L. E. Pepi, A. Shajahan, M. Wong, D. A. Scott, K. Matsumoto, Z.-J. Xia, C. B. Lebrilla, R. S. Haltiwanger, P. Azadi, H. H. Freeze

The paper shows that cells use different pools of GDP-fucose for glycosylation, depending on the origin of the monosaccharide, and that this selection is tightly regulated.

bioRxiv · Nov 3, 2021Biochemistry