The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection
A. Giraud-Gatineau, J. M. Coya, A. Maure, A. Biton, M. Thomson, E. M. Bernard, M. G. Gutierrez, G. Larrouy-Maumus, R. Brosch, B. Gicquel, L. Tailleux
The paper shows that bedaquiline reprograms macrophages to enhance bactericidal activity against bacteria through metabolic and lysosomal pathways.
bioRxiv · Sep 6, 2019Immunology