Author

E. M. Bernard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

M. G. Gutierrez· 3 shared B. Aylan· 2 shared C. Bussi· 2 shared E. Pellegrino· 2 shared P. Santucci· 2 shared A. Biton· 1 shared A. Fearns· 1 shared A. Giraud-Gatineau· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

M. G. Gutierrez

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

C. Bussi, T. Heunis, E. Pellegrino, E. M. Bernard, N. Bah, M. Silva Dos Santos, P. Santucci, B. Aylan, A. Rodgers, A. Fearns, J. Mitschke, C. Moore, J. I. MacRae, M. Greco, T. Reinheckel, , M. G. Gutierrez

This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.

bioRxiv · Aug 9, 2022Cell Biology

Visualizing pyrazinamide action by live single cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis

P. Santucci, B. Aylan, L. Botella, E. M. Bernard, C. Bussi, E. Pellegrino, N. Athanasiadi, M. G. Gutierrez

This paper uses live-cell imaging to show that pyrazinamide disrupts Mycobacterium tuberculosis intracellular pH homeostasis, unlike other antibiotics, and that this effect depends on host endolysosomal acidification and PncA activity.

bioRxiv · Dec 20, 2021Microbiology

The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

A. Giraud-Gatineau, J. M. Coya, A. Maure, A. Biton, M. Thomson, E. M. Bernard, M. G. Gutierrez, G. Larrouy-Maumus, R. Brosch, B. Gicquel, L. Tailleux

The paper shows that bedaquiline reprograms macrophages to enhance bactericidal activity against bacteria through metabolic and lysosomal pathways.

bioRxiv · Sep 6, 2019Immunology