Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
K. K. Lee, U. Lapinska, G. Tolle, M. Micaletto, B. Zhang, W. Phetsang, A. Verderosa, B. M. Invergo, J. Westley, A. Bebes, R. Yuecel, P. A. ONeill, A. Farbos, A. R. Jeffries, S. van Houte, , S. Pagliara
This study shows that subpopulations of stationary phase bacteria resist antimicrobial peptides through enhanced efflux and other mechanisms, and suggests combining tachyplesin with sertraline to combat resistance.
bioRxiv · Apr 22, 2024Microbiology