K. K. Lee

Functional regimes define the response of the soil microbiome to environmental change

The paper uses microcosm experiments and modeling to identify three functional regimes governing soil microbiome responses to pH changes, revealing distinct metabolic dynamics and underlying mechanisms.

Global patterns in gene content of soil microbiomes emerge from microbial interactions

The paper shows that environmental filtering alone cannot explain global patterns in soil microbiome gene content, as ecological interactions between genotypes drive observed associations with pH.

Combinatorial immune refocusing within the influenza hemagglutinin head elicits cross-neutralizing antibody responses

This study evaluates trihead nanoparticle immunogens to enhance cross-neutralizing antibody responses against influenza H1 viruses by combining immunofocusing techniques.

Novel mRNA-based VP8* vaccines against rotavirus are highly immunogenic in rodents

This study develops mRNA-based VP8* vaccines against rotavirus, showing immunogenicity in rodents with LS-P2-VP8* inducing superior humoral responses.

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection

This study identifies four broad, potent monoclonal antibodies against SARS-CoV-2 spike protein that neutralize multiple variants, including Omicron and XBB.1.5, targeting conserved regions with high functional constraint.

Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery

This study visualizes the membrane fusion process of Chikungunya virus using cryo-electron tomography, revealing conformational changes and structural features of the fusion machinery.

Fast bacterial growth reduces antibiotic accumulation and efficacy

The paper identifies fast-growing bacterial variants that avoid antibiotic accumulation and survive treatment without genetic mutations, challenging the current understanding of antibiotic resistance mechanisms.

Cryo-ET of HIV reveals Env positioning on Gag lattice and structural variation among Env trimers

This study uses cryo-ET to analyze HIV-1 Env structure and positioning in mature and immature virions, revealing structural variation and insights into Env incorporation and antigen presentation.

Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

Structure-based design of stabilized recombinant influenza neuraminidase tetramers

This study designs stabilized recombinant influenza neuraminidase tetramers by uncovering structural principles and improving thermal stability and antibody affinity.

Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design

This paper designs stabilized SARS-CoV-2 RBD variants using deep mutational scanning and structure-based design, showing improved thermal stability and manufacturability for vaccine applications.

Structurally related but genetically unrelated antibody lineages converge on an immunodominantHIV-1 Env neutralizing determinant following trimer immunization

The paper analyzes monoclonal antibodies from vaccinated non-human primates to identify a conserved immunodominant epitope in HIV-1 Env and how different lineages target it for potent neutralization.

Functional development of a V3-specific broadly neutralizing antibody isolated from a case of HIV superinfection

This study characterizes the development of a V3-specific broadly neutralizing antibody from an HIV superinfection case, revealing unique epitope recognition and escape mechanisms.

The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and metastasis-related processes through ZEB1/2

This study shows TRIP12 suppresses EMT and metastasis by inhibiting ZEB1/2 in breast cancer, based on patient data and cell experiments.

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies

This study reconstructs the developmental pathways of HIV-specific ADCC antibodies and identifies mutations required for antigen binding and ADCC function.

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

Nanoparticle immunogens with four seasonal influenza hemagglutinins elicit neutralizing antibodies against both the head and stem, providing broad protection against diverse influenza strains.

Direct Imaging of Liquid Domains in Membranes by Cryo Electron Tomography

This paper develops two methods to directly image and quantify submicron liquid domains in membranes using cryo-electron tomography, enabling analysis under native conditions.

Rapid development of an infant-derived HIV-1 broadly neutralizing antibody lineage

This study reconstructs the developmental lineage of an infant-derived HIV-1 broadly neutralizing antibody, showing a rapid evolution with fewer mutations compared to adult antibodies.