Author

B. J. Graves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

B. J. Madison· 2 shared K. A. Clark· 2 shared N. Bhachech· 2 shared S. L. Currie· 2 shared D. J. Bearss· 1 shared D. K. W. Lau· 1 shared H. Vankayalapati· 1 shared J. J. Doane· 1 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

B. J. Madison

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites

B. J. Madison, K. A. Clark, N. Bhachech, P. C. Hollenhorst, B. J. Graves, S. L. Currie

The paper shows that electrostatic repulsion between ETS and JUN-FOS proteins causes anticooperative DNA binding at ETS-AP1 sites, influencing their roles in prostate cancer.

bioRxiv · May 9, 2018Biochemistry

Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors

S. Currie, S. L. Warner, H. Vankayalapati, X.-H. Liu, S. Sharma, D. J. Bearss, B. J. Graves

The paper develops two in vitro assays to screen inhibitors of ETS transcription factors and finds that lower affinity DNA-binding sequences enhance compound inhibition.

bioRxiv · Aug 28, 2017Biochemistry

ETV4 And AP1 Transcription Factors Form Multivalent Interactions With Three Sites On The MED25 Activator-Interacting Domain

S. L. Currie, J. J. Doane, K. S. Evans, N. Bhachech, B. J. Madison, D. K. W. Lau, L. P. McIntosh, J. J. Skalicky, K. A. Clark, B. J. Graves

This study identifies multivalent interactions between ETV4, AP1 factors, and MED25, showing how these interactions enhance transcriptional regulation and are relevant in prostate cancer.

bioRxiv · Apr 11, 2017Biochemistry