This study shows that genetic diversity in C. elegans strains leads to varying toxicant responses, highlighting the need for genetically diverse strains in toxicological screening.

Toxicology · Sep 1, 2022Peer-reviewedPharmacology & Toxicology

Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of Caenorhabditis elegans across the Hawaiian Islands

T. A. Crombie, P. Battlay, R. E. Tanny, K. S. Evans, C. M. Buchanan, D. E. Cook, C. M. Dilks, L. A. Stinson, S. Zdraljevic, G. Zhang, N. M. Roberto, D. Lee, M. Ailion, K. A. Hodgins, E. C. Andersen

This study samples C. elegans across Hawaii over three years, sequenced their genomes, and found seven genetic groups and 18 regions linked to local adaptation.

bioRxiv · Oct 11, 2021Ecology

Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations

T. A. Crombie, S. Zdraljevic, D. E. Cook, R. E. Tanny, S. C. Brady, Y. Wang, K. S. Evans, S. Hahnel, D. Lee, B. C. Rodriguez, G. Zhang, J. van der Zwaag, K. C. Kiontke, E. C. Andersen

The paper samples Hawaiian C. elegans strains, revealing high genetic diversity and admixture with global populations, suggesting ancestral diversity preserved in Hawaii.

bioRxiv · Jul 28, 2019Ecology

ETV4 And AP1 Transcription Factors Form Multivalent Interactions With Three Sites On The MED25 Activator-Interacting Domain

S. L. Currie, J. J. Doane, K. S. Evans, N. Bhachech, B. J. Madison, D. K. W. Lau, L. P. McIntosh, J. J. Skalicky, K. A. Clark, B. J. Graves

This study identifies multivalent interactions between ETV4, AP1 factors, and MED25, showing how these interactions enhance transcriptional regulation and are relevant in prostate cancer.

bioRxiv · Apr 11, 2017Biochemistry