Author

L. P. McIntosh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. A. N. Gerak· 2 shared M. Roberge· 2 shared R. B. Sessions· 2 shared A. D. Balgi· 1 shared B. J. Graves· 1 shared B. J. Madison· 1 shared D. K. W. Lau· 1 shared I. J. Sadowski· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

C. A. N. Gerak

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3 papers

Recent·Most cited

Biophysical characterization of the ETV6 PNT domain polymerization interfaces

C. A. N. Gerak, S. Y. Cho, M. Kolesnikov, M. Okon, M. E. P. Murphy, R. B. Sessions, M. Roberge, L. P. McIntosh

This study characterizes the biophysical properties of the ETV6 PNT domain polymerization interfaces to identify potential drug targets for inhibiting its self-association.

bioRxiv · Aug 21, 2020Biochemistry

A Multi-pronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization

C. A. N. Gerak, S. M. Zhang, A. D. Balgi, I. J. Sadowski, R. B. Sessions, L. P. McIntosh, M. Roberge

This study develops experimental and computational assays to identify small molecule inhibitors of ETV6 PNT domain polymerization, finding no direct binders but gaining insights for future therapeutic development.

bioRxiv · Aug 20, 2020Biochemistry

ETV4 And AP1 Transcription Factors Form Multivalent Interactions With Three Sites On The MED25 Activator-Interacting Domain

S. L. Currie, J. J. Doane, K. S. Evans, N. Bhachech, B. J. Madison, D. K. W. Lau, L. P. McIntosh, J. J. Skalicky, K. A. Clark, B. J. Graves

This study identifies multivalent interactions between ETV4, AP1 factors, and MED25, showing how these interactions enhance transcriptional regulation and are relevant in prostate cancer.

bioRxiv · Apr 11, 2017Biochemistry