Author

B. J. Laight

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

K. Tyryshkin· 2 shared M. Koti· 2 shared A. Asante· 1 shared A. Garven· 1 shared A. Hamade· 1 shared A. L. Simpson· 1 shared A. W. Craig· 1 shared C. Graham· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

K. Tyryshkin

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2 papers

Recent·Most cited

Fes-deficient macrophages enhance CD8+ T cell priming and tumour control through increased proinflammatory cytokine production and localization

B. J. Laight, D. Harper, N. Dmytryk, S. Zhang, A. Garven, C. Shi, R. Nauman, J. Kment, F. Alotaibi, I. Shapovalov, Y. Gao, J. Mewburn, C. Vlasschaert, D. LeBrun, K. Tyryshkin, , P. A. Greer

bioRxiv · Feb 27, 2024 · PreprintImmunology

PTEN and BRCA1 tumor suppressor loss associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in a murine model of ovarian cancer

N. Shakfa, D. Li, G. Conseil, E. D. Lightbody, J. Wilson-Sanchez, A. Hamade, S. Chenard, B. J. Laight, A. Asante, K. Tyryshkin, M. Köbel, M. Koti

This study examines how PTEN and BRCA1 loss in ovarian cancer affects tumor immune microenvironment response to STING pathway activation, showing improved survival in PTEN-deficient tumors with STING therapy.

bioRxiv · Jun 27, 2022 · PreprintImmunology