Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection
D. Schultz, R. Johnson, K. Ayyanathan, J. Miller, K. Whig, B. Kamalia, M. Dittmar, S. Weston, H. Hammond, C. Dillen, L. Castellana, J. S. Lee, M. Li, E. M. Lee, S. Constant, , S. Cherry
The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.
bioRxiv · Jun 24, 2021 · PreprintMicrobiology