Author

K. Ayyanathan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. Miller· 3 shared S. Cherry· 3 shared D. C. Schultz· 2 shared D. McCracken· 2 shared F. J. Rauscher· 2 shared J. S. Lee· 2 shared K. Whig· 2 shared M. Dittmar· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

J. Miller

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy.

J. S. Lee, M. Dittmar, J. Miller, M. Li, K. Ayyanathan, M. B. Ferretti, J. Hulahan, K. Whig, Z. Etwebi, T. Griesman, D. C. Schultz, S. Cherry

This study identifies how SARS-CoV-2 evolves to counteract host interferon signaling through interactions with autophagy pathways.

bioRxiv · Nov 13, 2023 · PreprintMicrobiology

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states

S. Reffsin, J. Miller, K. Ayyanathan, M. C. Dunagin, N. Jain, D. C. Schultz, S. Cherry, A. Raj

This study identifies cell state variability as a key determinant of SARS-CoV-2 susceptibility by analyzing highly susceptible lung epithelial cells.

bioRxiv · Jul 6, 2023 · PreprintBioengineering

Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection

D. Schultz, R. Johnson, K. Ayyanathan, J. Miller, K. Whig, B. Kamalia, M. Dittmar, S. Weston, H. Hammond, C. Dillen, L. Castellana, J. S. Lee, M. Li, E. M. Lee, S. Constant, , S. Cherry

The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.

bioRxiv · Jun 24, 2021 · PreprintMicrobiology

Kinetics characterization of ASXL1/2-mediated allosteric regulation of BAP1 deubiquitinase

H. Peng, J. Cassel, D. McCracken, J. W. Prokop, P. R. Collop, A. Polo, S. Joshi, J. P. Mandell, K. Ayyanathan, D. Hinds, S. B. Malkowicz, J. W. Harbour, A. M. Bowcock, J. Salvino, E. J. Kennedy, , F. J. Rauscher

This study characterizes the kinetics and stoichiometry of BAP1 and ASXL2 interactions, revealing their structural and functional properties in deubiquitinase activity.

bioRxiv · Feb 24, 2020Cancer Biology

Twist, Snail, and Sox9 form an allosterically regulated complex, the EMTosome, on a bipartite E-box site.

D. McCracken, H. P. Peng, K. Ayyanathan, Y. L. Jiang, S. Welsh, J. Yang, E. Kennedy, F. J. Rauscher, A. Gardini, F. J. Rauscher

The paper identifies a ternary complex, EMTosome, formed by Twist, Snail, and Sox9 that allosterically regulates Twist DNA binding during EMT.

bioRxiv · Feb 3, 2020 · PreprintCancer Biology