J. Miller

Persistent Activation of Chronic Inflammatory Pathways in Long Covid

The paper identifies persistent activation of inflammatory pathways in Long Covid patients compared to controls and links acute infection severity to Long Covid development.

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells

This study shows that an ADAM17-blocking antibody enhances IL-15-mediated NK cell activation and proliferation through CD16A and CD137, with potential therapeutic applications in cancer.

Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy.

This study identifies how SARS-CoV-2 evolves to counteract host interferon signaling through interactions with autophagy pathways.

T cells Use Focal Adhesions to Pull Themselves Through Confined Environments

This study shows that Th1 T cells use integrin-mediated focal adhesions to migrate through confined environments by pulling themselves forward.

Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.2.86

This study evaluates the neutralization escape of the SARS-CoV-2 Omicron subvariant BA.2.86 compared to other variants, finding lower neutralization by antibodies than BA.2 but comparable to circulating variants.

Toxicokinetic Characterization of the Inter-Species Differences in 6PPD-Quinone Toxicity Across Seven Fish Species: Metabolite Identification and Semi-Quantification

This study identifies and semi-quantifies 6PPD-Quinone metabolites in fish species to explore inter-species differences in toxicity and detoxification.

Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19

The paper identifies profibrotic monocyte-derived alveolar macrophages and neutrophil recruitment as drivers of lung fibrosis in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.

Combination-Based Drug Screening for Induced Oligodendrocyte Differentiation Enables Mechanistic Insight and Identifies Optimal Drug Pairs for Remyelination

The paper identifies drug pairs for remyelination using combination screening and provides mechanistic insights into their efficacy and toxicity.

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states

This study identifies cell state variability as a key determinant of SARS-CoV-2 susceptibility by analyzing highly susceptible lung epithelial cells.

Waning Immunity Against XBB.1.5 Following Bivalent mRNA Boosters

This study evaluates the durability of humoral and cellular immune responses to XBB.1.5 after bivalent mRNA boosters, finding waning neutralizing antibody titers but preserved T cell responses.

Metabolic clearance rate modeling: A translational approach to quantifying cerebral metabolism using hyperpolarized pyruvate.

This paper introduces a model-free method to quantify cerebral metabolism using hyperpolarized pyruvate MRI and demonstrates its application in pre-clinical stroke and healthy human brain studies.

Substantial Neutralization Escape by the SARS-CoV-2 Omicron Variant BQ.1.1

The paper shows BQ.1.1 SARS-CoV-2 variant has greater neutralization escape compared to BA.5, with lower NAb titers in vaccinated individuals.

Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters

This study compares neutralizing antibody titers after monovalent and bivalent mRNA boosters against SARS-CoV-2, finding comparable levels against BA.5.

Vaccine Protection Against the SARS-CoV-2 Omicron Variant in Macaques

This study evaluates vaccine efficacy against SARS-CoV-2 Omicron in macaques, finding that both humoral and cellular immune responses are necessary for virologic control.

Mathematical modeling suggests cooperation of plant-infecting viruses

The paper uses mathematical modeling to analyze viral infection dynamics in plants, finding evidence of cooperation between viral strains and highlighting limitations in experimental data for determining dissemination pathways.

The crucial role of genome-wide genetic variation in conservation

This paper evaluates the feasibility of focusing conservation efforts on functional genetic variation versus genome-wide genetic variation, finding that the latter is more effective in preventing inbreeding depression and loss of adaptive potential.

Using stationary vital rates in impact assessments may underestimate potential threat

This study shows that including temporal trends in vital rates improves PVA accuracy and threat projections for declining populations.

Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection

The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.

Distinct movement patterns generate stages of spider web-building

This study quantifies spider web-building stages using movement patterns and identifies shared and stage-specific behaviors in orb-weaver spiders.

The FDA-approved drug apremilast suppresses alcohol intake: clinical and pre-clinical validation

This study shows that the FDA-approved drug apremilast reduces excessive alcohol drinking in both preclinical models and human studies.

Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents

The paper validates in vitro human lung tissue models for studying SARS-CoV-2 and influenza virus infections and antiviral treatments.

Structure-guided microbial targeting of antistaphylococcal prodrugs

This study identifies microbial esterases in Staphylococcus aureus and determines their substrate specificities to guide the design of serum esterase-resistant antistaphylococcal prodrugs.

The malaria metabolite HMBPP does not trigger erythrocyte terpene production

The paper investigates whether the malarial metabolite HMBPP increases erythrocyte -pinene levels, finding no significant change despite previous suggestions.

The clinical and molecular significance associated with STING signaling in estrogen receptor-positive early breast cancer

The paper identifies perinuclear STING (pnSTING) in ER+ breast cancer as a prognostic marker linked to immune infiltration and poor outcomes in low pnSTING tumors.

GATA4, expressed in Barrett's esophagus and esophageal adenocarcinoma, can block squamous epithelial cell gene expression in human esophageal cells

This study shows that GATA4, expressed in Barrett's esophagus and esophageal adenocarcinoma, represses squamous epithelial cell genes by directly binding to their promoters.

Bone marrow transplantation rescues monocyte recruitment defect and improves cystic fibrosis in mice

This study shows bone marrow transplantation improves survival and reduces inflammation in CFTRΔF508 mice by rescuing monocyte adhesion defects.

Social tolerance in Octopus laqueus - a maximal entropy model

This study investigates social tolerance and repulsion in Octopus laqueus by observing den occupancy patterns and finds they align with a maximum entropy model.

Thymic Stromal Lymphopoietin Promotes Proliferation and Contractility of Human Pulmonary Artery Smooth Muscle

This study shows TSLP enhances hypoxia-induced PA smooth muscle proliferation and contractility via Stat3 and PI3/Akt pathways, linking inflammation to pulmonary hypertension.

Length-independent telomere damage drives cardiomyocyte senescence

This study shows that telomere damage independent of length causes cardiomyocyte senescence, leading to cardiac dysfunction, and that clearing senescent cells improves cardiac health.

Rhamnolipids from Pseudomonas aeruginosa disperse the Biofilms of Sulfate-Reducing Bacteria

This study shows that Pseudomonas aeruginosa supernatants, containing rhamnolipids, effectively disperse biofilms of sulfate-reducing bacteria and other microbes.