Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
T. Zhang, A. Ambrodji, H. Huang, K. J. Bouchonville, A. S. Etheridge, R. E. Schmidt, B. M. Bembenek, Z. B. Temesgen, Z. Wang, F. Innocenti, D. Stroka, R. B. Diasio, C. R. Largiader, S. M. Offer
The paper identifies a germline variant that regulates DPYD gene expression through an enhancer, affecting 5-FU drug resistance.
bioRxiv · Nov 1, 2023 · PreprintPharmacology & Toxicology