Computationally designed GPCR quaternary structures bias signaling pathway activation
J. S. Paradis, X. Feng, B. Murat, R. E. Jefferson, M. E. Szpakowska, M. Hogue, N. D. Bergkamp, F. M. Heidenreich, M. J. Smit, A. Chevigne, M. Bouvier, P. Barth
The paper designs GPCR quaternary structures to bias signaling pathway activation and identifies a conformational switch controlling G protein vs β-arrestin recruitment.
bioRxiv · Sep 23, 2021Biophysics