Author

M. Hogue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Bouvier· 2 shared A. Chevigne· 1 shared A. Mancini· 1 shared A. S. Hauser· 1 shared B. Breton· 1 shared B. Murat· 1 shared C. Avet· 1 shared C. Le Gouill· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

M. Bouvier

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2 papers

Recent·Most cited

Computationally designed GPCR quaternary structures bias signaling pathway activation

J. S. Paradis, X. Feng, B. Murat, R. E. Jefferson, M. E. Szpakowska, M. Hogue, N. D. Bergkamp, F. M. Heidenreich, M. J. Smit, A. Chevigne, M. Bouvier, P. Barth

The paper designs GPCR quaternary structures to bias signaling pathway activation and identifies a conformational switch controlling G protein vs β-arrestin recruitment.

bioRxiv · Sep 23, 2021Biophysics

Effector membrane translocation biosensors reveal G protein and β-arrestin coupling profiles of 100 therapeutically relevant GPCRs

C. Avet, A. Mancini, B. Breton, C. Le Gouill, A. S. Hauser, C. Normand, H. Kobayashi, F. Gross, M. Hogue, V. Lukasheva, S. St-Onge, M. Carrier, M. Heroux, S. Morissette, E. Fauman, , M. Bouvier

The paper develops EMTA biosensors to profile G protein and β-arrestin coupling of 100 GPCRs, revealing diverse signaling profiles and drug-target interactions.

bioRxiv · Apr 20, 2020Pharmacology & Toxicology